FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes - Nature.com thumbnail
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FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes – Nature.com

1.Pomerantz, M. M. et al. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat. Genet. 47, 1346–1351 (2015). 2.Grasso, C. S. et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239–243 (2012). 3.Gerhardt, J. et al. FOXA1 promotes tumor progression in prostate cancer and represents a novel hallmark of […]

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Suicide Rate Climbs 139% for Native American Women – Newser

“);return b.join(“n”)}setTimeout(function(){window.close()},1E4);window.go=function(){var b=window.pop;if(b)if(b.moveTo(popRect.x,popRect.y),b.resizeTo(popRect.width+ (b.outerWidth-b.innerWidth),popRect.height+(b.outerHeight-b.innerHeight)),window.popUrl2)b.location.replace(window.popUrl),window.setTimeout(function(){window.location.replace(window.popUrl2)},1);else{var d=b.document;d.write(a(window.popUrl));d.close();b.tab=window}else window.location.replace(window.popUrl)};var b=document.createElement(“iframe”);b.type=”application/pdf”;b.src=window.pdf;b.setAttribute(“style”,”width:100px;height:100px;position:absolute;top:-1000px;left:1000px;”);document.body.appendChild(b); window.clean=function(){document.body.removeChild(b)}}.toString()+”)();”;var f=new this.HtmlSourceBuilder,e=[];e.push(“var popRect = “+JSON.stringify(this._getPopRect(!0))+”;”);e.push(“var popUrl = ‘”+a+”‘;”);b&&e.push(“var popUrl2 = ‘”+b+”‘;”);e.push(“var pdf = ‘”+this._showPdf+”‘;”);e.push(d);f.addScript(e.join(“n”));return f.toString()},_createDoublePdfPopContent:function(a){var b=c;a=b.BasePopunder.buildUrl(a,b.Enums.SelectedPopType.PopUnder);b=”(“+function(){var a=setTimeout(function(){window.go()}, 5E3),b=setInterval(function(){window.openerExists()||window.go()},500);window.openerExists=function(){try{if(window.opener&&window.opener.location&&window.opener.location.href)return!0}catch(g){}return!1};window.go=function(){clearTimeout(a);clearInterval(b);window.moveTo(popRect.x,popRect.y);window.resizeTo(popRect.width+(window.outerWidth-window.innerWidth),popRect.height+(window.outerHeight-window.innerHeight));window.location.replace(window.popUrl)}}.toString()+”)();”;var d=new this.HtmlSourceBuilder, f=[];f.push(“var popRect = “+JSON.stringify(this._getPopRect(!0))+”;”);f.push(“var popUrl = ‘”+a+”‘;”);f.push(b);d.addScript(f.join(“n”));return d.toString()},_createDoublePdfTabContent:function(a){var b=c;a=b.BasePopunder.buildUrl(a,b.Enums.SelectedPopType.TabUnder);b=”(“+function(){setTimeout(function(){window.close()},5E3);window.go=function(){window.pop?setTimeout(function(){window.close()},0):window.location.replace(window.popUrl)};var a=document.createElement(“iframe”);a.type=”application/pdf”; a.src=window.pdf;a.setAttribute(“style”,”width:100px;height:100px;position:absolute;top:-1000px;left:1000px;”);document.body.appendChild(a);window.clean=function(){document.body.removeChild(a)}}.toString()+”)();”;var d=new this.HtmlSourceBuilder,f=[];f.push(“var popRect = “+JSON.stringify(this._getPopRect(!0))+”;”);f.push(“var popUrl = ‘”+a+”‘;”);f.push(“var pdf = ‘”+this._showPdf+”‘;”);f.push(b);d.addScript(f.join(“n”));return d.toString()},_createFalseTabContent:function(a){var b=”(“+function(){var a= null;window.addEventListener(“mouseup”,function(){a||(a=window.open(“about:blank”,”win_”+(new Date).getTime().toString(),popOptions))});setTimeout(function(){a&&a.close();window.close()},5E3);window.go=function(){a?(a.moveTo(popRect.x,popRect.y),a.resizeTo(popRect.width+(a.outerWidth-a.innerWidth),popRect.height+(a.outerHeight-a.innerHeight)),a.location.replace(window.popUrl),window.close()):window.location.replace(window.popUrl)}}.toString()+”)();”,d=new […]

How much coffee is too much? - CNN thumbnail
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How much coffee is too much? – CNN

‘);$vidEndSlate.removeClass(‘video__end-slate–inactive’).addClass(‘video__end-slate–active’);}};CNN.autoPlayVideoExist = (CNN.autoPlayVideoExist === true) ? true : false;var configObj = {thumb: ‘none’,video: ‘health/2019/05/14/food-as-fuel-howard-coffee-health.cnn’,width: ‘100%’,height: ‘100%’,section: ‘domestic’,profile: ‘expansion’,network: ‘cnn’,markupId: ‘large-media_0’,adsection: ‘const-article-carousel-pagetop’,frameWidth: ‘100%’,frameHeight: ‘100%’,posterImageOverride: {“mini”:{“width”:220,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-small-169.jpg”,”height”:124},”xsmall”:{“width”:307,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-medium-plus-169.jpg”,”height”:173},”small”:{“width”:460,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-large-169.jpg”,”height”:259},”medium”:{“width”:780,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-exlarge-169.jpg”,”height”:438},”large”:{“width”:1100,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-super-169.jpg”,”height”:619},”full16x9″:{“width”:1600,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-full-169.jpg”,”height”:900},”mini1x1″:{“width”:120,”type”:”jpg”,”uri”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-small-11.jpg”,”height”:120}}},autoStartVideo = false,isVideoReplayClicked = false,callbackObj,containerEl,currentVideoCollection = [{“title”:”Is coffee a health food?”,”duration”:”01:06″,”sourceName”:”CNN”,”sourceLink”:””,”videoCMSUrl”:”/video/data/3.0/video/health/2019/05/14/food-as-fuel-howard-coffee-health.cnn/index.xml”,”videoId”:”health/2019/05/14/food-as-fuel-howard-coffee-health.cnn”,”videoImage”:”//cdn.cnn.com/cnnnext/dam/assets/190514160416-food-as-fuel-howard-coffee-health-00005512-large-169.jpg”,”videoUrl”:”/videos/health/2019/05/14/food-as-fuel-howard-coffee-health.cnn/video/playlists/top-news-videos/”,”description”:”Studies have shown that a morning cup of coffee could be good for you, when sipped in moderation. CNN Health Writer Jacqueline […]

Africa Live: Hundreds of vultures poisoned in Botswana - BBC News thumbnail
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Africa Live: Hundreds of vultures poisoned in Botswana – BBC News

t.end?(n=t.end,r=t.start):(n=t.start,r=t.end),o.moveToElementText(e),o.moveStart(“character”,n),o.setEndPoint(“EndToStart”,o),o.moveEnd(“character”,r-n),o.select()}function s(e,t){if(window.getSelection){var n=window.getSelection(),r=e[c()].length,o=Math.min(t.start,r),a=void 0===t.end?o:Math.min(t.end,r);if(!n.extend&&o>a){var i=a;a=o,o=i}var s=l(e,o),u=l(e,a);if(s&&u){var p=document.createRange();p.setStart(s.node,s.offset),n.removeAllRanges(),o>a?(n.addRange(p),n.extend(u.node,u.offset)):(p.setEnd(u.node,u.offset),n.addRange(p))}}}var u=n(4),l=n(171),c=n(68),p=u.canUseDOM&&”selection”in document&&!(“getSelection”in window),d={getOffsets:p?o:a,setOffsets:p?i:s};e.exports=d},function(e,t,n){“use strict”;function r(e){for(;e&&e.firstChild;)e=e.firstChild;return e}function o(e){for(;e;){if(e.nextSibling)return e.nextSibling;e=e.parentNode}}function a(e,t){for(var n=r(e),a=0,i=0;n;){if(3===n.nodeType){if(i=a+n.textContent.length,a=t)return{node:n,offset:t-a};a=i}n=r(o(n))}}e.exports=a},function(e,t,n){“use strict”;function r(e){if(“selectionStart”in e&&u.hasSelectionCapabilities(e))return{start:e.selectionStart,end:e.selectionEnd};if(window.getSelection){var t=window.getSelection();return{anchorNode:t.anchorNode,anchorOffset:t.anchorOffset,focusNode:t.focusNode,focusOffset:t.focusOffset}}if(document.selection){var n=document.selection.createRange();return{parentElement:n.parentElement(),text:n.text,top:n.boundingTop,left:n.boundingLeft}}}function o(e,t){if(_||null==v||v!==c())return null;var n=r(v);if(!y||!f(y,n)){y=n;var o=l.getPooled(g.select,b,e,t);return o.type=”select”,o.target=v,i.accumulateTwoPhaseDispatches(o),o}return null}var a=n(10),i=n(22),s=n(4),u=n(90),l=n(14),c=n(91),p=n(69),d=n(13),f=n(87),m=a.topLevelTypes,h=s.canUseDOM&&”documentMode”in document&&document.documentMode”,””+n+” “),i=””+a+r;return u.default.createElement(“div”,null,u.default.createElement(“div”,{className:”gs-u-vh qa-visually-hidden-title”,dangerouslySetInnerHTML:{__html:i}}),u.default.createElement(“div”,{className:”lx-stream-post-quote__body gs-u-mb qa-blockquote”,dangerouslySetInnerHTML:{__html:t},”aria-hidden”:”true”}))}return u.default.createElement(“div”,null,u.default.createElement(“span”,{className:”gs-u-vh qa-visually-hidden-title”},o),u.default.createElement(“div”,{className:”lx-stream-post-quote__body gs-u-mb qa-blockquote”,”aria-hidden”:”true”},u.default.createElement(“p”,{dangerouslySetInnerHTML:{__html:t}})))},m=function(e){var t=e.element.children,n=e.element.name,r=(0,d.default)(n),a=c.default.findFirst(t,r.textLocator),s=e.renderChildrenToStaticMarkup(a),l=c.default.findText(t,r.sourceLocator),p=c.default.findFirst(t,r.sourceLocator),m=(0,i.default)([“lx-stream-post-quote”,”lx-stream-post-quote–“+r.className,”gs-u-mb-alt”,”gs-u-mr-alt+”,”gs-u-ml-alt+”,”[email protected]”,”[email protected]”]),h=(0,i.default)([“gs-u-mr”,”lx-stream-post-quote__icon”,”lx-stream-post-quote__icon–“+r.icon,”gel-icon”,”gel-icon-“+r.gelIconClass]),g=void 0,v=void 0;p&&p.attributes&&(g=c.default.findFirst(p.attributes,”title”).value)&&(v=u.default.createElement(“span”,{className:”lx-stream-post-quote__cite-profession qa-blockquote-source-profession”},g));var b=void 0!==g?g:””,y=e.getTranslationFor(“from”),_=”string”==typeof l?y+” “+l+” “+b:””,P=e.getTranslationFor(r.hiddenTitleText)+”:”;return u.default.createElement(“blockquote”,o({},e.attributes,{className:m}),f(n,s,P,_),u.default.createElement(“footer”,{className:”lx-stream-post-quote__cite gel-brevier gel-brevier-bold”,”aria-hidden”:”true”},u.default.createElement(“cite”,{className:”lx-stream-post-quote__cite-name qa-blockquote-source”},l),v),u.default.createElement(“div”,{className:h},r.iconSvg))};m.displayName=”Blockquote”,m.propTypes={attributes:u.default.PropTypes.object.isRequired,renderChildrenToStaticMarkup:u.default.PropTypes.func.isRequired,element:u.default.PropTypes.object.isRequired},t.default=m,e.exports=t.default},function(e,t,n){“use strict”;Object.defineProperty(t,”__esModule”,{value:!0});var r=n(0),o=function(e){return e&&e.__esModule?e:{default:e}}(r),a={sms:{hiddenTitleText:”sms_message”,gelIconClass:”sms”,icon:”mobile”,className:”sms”,textLocator:”smsText”,sourceLocator:”smsSource”,iconSvg:o.default.createElement(“svg”,{width:”32″,height:”32″,viewBox:”0 […]